GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | MALL | chr2:110841452-110874143:- | 0.29 | 5.97 | 4.71E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | NKX6-1 | chr4:85414436-85419387:- | 0.49 | 8.44 | 3.89E-16 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10739496 | chr9:100552559 | TTC8 | chr14:89290497-89344334:+ | 0.25 | 6.11 | 2.11E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10759927 | chr9:100542176 | CLDN2 | chrX:106143394-106174091:+ | 0.27 | 6.08 | 2.45E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10759927 | chr9:100542176 | EML5 | chr14:89081205-89259157:- | 0.29 | 6.69 | 6.16E-11 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10759927 | chr9:100542176 | EPDR1 | chr7:37960163-37991539:+ | 0.32 | 7 | 8.99E-12 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10759927 | chr9:100542176 | LRRC42 | chr1:54412037-54433839:+ | -0.24 | -6.2 | 1.23E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10759927 | chr9:100542176 | NKX6-1 | chr4:85414436-85419387:- | 0.5 | 8.7 | 5.52E-17 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs965513 | 1 | rs10759927 | chr9:100542176 | PLCE1 | chr10:95753746-96088146:+ | 0.27 | 6.2 | 1.22E-9 | Thyroid cancer (Papillary, radiation-related);Thyroid cancer |
| THCA | trans | rs1056667 | 1 | rs1078679 | chr6:26568741 | ZNF322B | chr9:99957633-99961910:- | 0.59 | 11.32 | 1.79E-26 | Educational attainment |
| THCA | trans | rs6600671 | 1 | rs10794671 | chr1:121168242 | NBPF14 | chr1:148003643-148346791:- | 0.44 | 10.33 | 1.04E-22 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs10903159 | chr1:121181997 | NBPF14 | chr1:148003643-148346791:- | 0.43 | 10.32 | 1.08E-22 | Hip geometry |
| THCA | trans | rs6600671 | 1 | rs10903161 | chr1:121178741 | NBPF14 | chr1:148003643-148346791:- | 0.41 | 9.7 | 1.99E-20 | Hip geometry |
| THCA | trans | rs1056667 | 1 | rs10946834 | chr6:26533664 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.29 | 1.42E-22 | Educational attainment |
| THCA | trans | rs1056667 | 1 | rs10946835 | chr6:26533757 | ZNF322B | chr9:99957633-99961910:- | 0.54 | 10.29 | 1.42E-22 | Educational attainment |